|
KMID : 0043320070300121629
|
|
Archives of Pharmacal Research
2007 Volume.30 No. 12 p.1629 ~ p.1634
|
|
|
The Effects of Rutaecarpine on the Pharmacokinetics of Acetaminophen in Rats
|
|
Lee Sang-Kyu
Bista Sudeep R.
Jeong He-Min
Kim Dong-Hyeon
Kang Mi-Jeong
Jahng Yurng-Dong
|
|
|
Abstract
|
|
|
Rutaecarpine, an alkaloid originally isolated from the unripe fruit of Evodia rutaecarpa, has
been shown to be anti-inflammatory as it inhibits cyclooxygenase-2. It induces the activities of
hepatic CYP 1A2, 2B, and 2E1 in rats. A possible interaction between rutaecarpine and acetaminophen
(APAP) was investigated in male Sprague Dawley rats in the present study. When
25 mg/kg APAP was intravenously administered concurrently with 80 mg/kg rutaecarpine, the
area under the curve of APAP in plasma was significantly decreased when compared to that of
APAP alone. When the rats were pre-treated orally with 40 and 80 mg/kg rutaecarpine for 3
days, the % value of Cmax and area under the curve of acetaminophen-sulfate conjugate were
significantly decreased to 56.4% and 61.7% of the vehicle control group, respectively. These
results suggest that rutaecarpine might cause changes in the pharmacokinetic parameters of
APAP in rats.
|
|
|
KEYWORD
|
|
|
Rutaecarpine, Acetaminophen, Interaction, Cytochrome P450, Sulfation, Rat
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|